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February 4, 2026: Washington, DC A year ago, theNational Consumers League took the unusual step offlaggingwarningsfromthe Food and Drug Administration(FDA) and medical societiesstatingthatcompounded versions of GLP-1 (glucagon-like peptide-1 receptor agonists)weight-lossdrugs are not FDA approved and may cause serious health problems.The purposewas toinformconsumers aboutthe potential harm posed by these drugsbeforeHims & Hers, a large telehealth company,aired awidely hyped television ad duringthe 2025 Super Bowl touting only the benefitsof compoundedGLP-1s.

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In the current review, we discussed the dysregulation of IGF-1/GLP-1 signaling in neurodegenerative manifestations of ALS like a genetic anomaly, oligodendrocyte degradation, demyelination, glial overactivation, immune deregulation, and neuroexcitation

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