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The primary mechanism involves metabolic adaptation, a well-documented phenomenon in which the body reduces energy expenditure in response to sustained caloric deficit and weight loss

Food & Drug Administration (FDA)

The elimination half-life is roughly five days, so a single dose takes about four to five weeks to clear almost completely

Caught in the middle While the battle over diabetes and weight-loss drugs is unprecedented, the drug companies aren't exactly using a new playbook, says Feldman, the law professor at the University of California