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Lancet Diabetes Endocrinol 10(1):4657

doi: 10.1016/j.atherosclerosis.2019.11.021

Alzheimers and dementia A paper published in January 2025 using US Department of Veterans Affairs data of nearly 2.5 million patients found that people prescribed GLP-1 drugs had a lower relative risk of developing dementia compared with those who took other drugs for diabetes

GLP-1 medications, such as semaglutide and tirzepatide, mimic hormones naturally found in the body to support appetite control, blood sugar regulation, and weight loss

In an in vitro study, tirzepatide elicited a cAMP response in a human pancreatic -cell line that was significantly higher than that observed for either GLP-1 or GIP alone, indicating a synergistic or additive activation of signaling in pancreatic -cells by GIP and GLP-1 (63)