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Safety vigilance, thoughtful patient selection, and integration with behavioural care are the practical requirements for translating trial efficacy into real-world benefit

March 31, 2026

We anticipated the follow-up to be differential between the exposure groups but not likely to be associated with the outcome

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had taken a glucagon-like peptide-1 (GLP-1) receptor agonist medications for the treatment of type 2 diabetes or, increasingly, for weight loss

A significance level of alpha = 0.05 was adopted for all analyses