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This view suggests that semaglutide captures most of the available benefit from incretin-based therapy, and tirzepatides advantage comes from fine-tuning rather than fundamentally different mechanisms

SGLT2 inhibitors have proven efficacy in slowing chronic kidney disease progression, reducing albuminuria, and decreasing risk of end-stage renal disease

While there's no direct proof that these GLP-1 drugs are driving the drops we're now seeing in obesity rates, given their increasing use and how effective we know they are, it seems likely

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