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42) In SUSTAIN-6, patients treated with semaglutide had a lower risk of developing or worsening nephropathy, but a higher risk of complications from diabetic retinopathy than those receiving placebo (40)

Compared to lifestyle interventions without medications, GLP-1-assisted programmes have been shown to lead to a more clinically significant weight loss of 10% or more

Individuals have a higher risk of gaining the weight back if they do not keep up with the healthy lifestyle changes they made

Although GLP-1R expression is relatively low in many peripheral organs, GLP-1 medicines exert distinct antiinflammatory effects through both direct and indirect mechanisms that involve immune, vascular, and neural crosstalk (Figure 4)
Risks include gastrointestinal side effects, pancreatitis, gallbladder disease, and a boxed warning for thyroid C-cell tumors

J Diabetes Res 2021
