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The use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has revolutionized the treatment of Type 2 Diabetes Mellitus (T2DM)

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Absolute and relative loss of total lean body mass, assessed via DXA scan, is often used as surrogate endpoint for measuring the impact on muscle mass, despite its obvious limitations, e.g., including the weight of organs, bones, tissue and fluids in addition to muscle

Clinical studies have shown that continuous use of Rybelsus can lead to significant and sustained weight reduction

Limited evidence suggests that combined SGLT2is/GLP1-RAs therapy can potentially improve most but not all outcomes