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Description
Under ischemic and high-stress conditions, GLP-1R activation increases myocardial glucose uptake and glycolytic flux while inhibiting caspase-3mediated cardiomyocyte apoptosis

These differences can predict who experiences more GI side effects

Symptoms of elevated blood glucose include increased thirst, frequent urination, fatigue, and blurred vision

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Continued escalation for those tolerating the medication well

Ro sticks to brand-name only: Wegovy, Zepbound, cash-pay Ozempic, and a new oral orforglipron option added in April 2026
