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To develop novel protease inhibitors with high activity and selectivity, grassypeptolide 59 was synthesized by Jason C

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A synthetic form of this peptide, called Exenatide, was the first incretin analog approved by the US FDA to treat diabetes

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Post-hoc adjustments for slight differences in HbA1c levels (~0.3%) during the first 3 months of the trial attenuated the lixisenatide-induced renal benefit ( p = 0.07), suggesting some glucose-dependency

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