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Grenon SM, Vittinghoff E, Owens CD, Conte MS, Whooley M, Cohen BE

Differentiation of the mesenchymal stem cells to pancreatic beta-like cells in alginate/trimethyl chitosan/alginate microcapsules

It acts directly on several target tissues, including skeletal muscle and bone, but several effects are mediated indirectly by circulating (liver-derived) or locally produced IGF-1

Limited insurance coverage and affordability issues create barriers to widespread patient access, particularly in lower-income populations and countries with stringent pricing regulations

What other generic GLP-1s could we see in the U.S

Note that GLP-1 is not the only hormone that binds to and signals via the GLP-1R