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Front Med Lausanne 10:1089099 Herrlinger KR, Stange EF (2023) Prioritization in inflammatory bowel disease therapy

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The deep short axon cells (dSACs) in the granule cell layer (GCL) of olfactory bulb, named PPG neurons, could synthesize and release GLP-1 and in turn modulate the activity of the first-order neurons, mitral cells (MCs) which are the primary projection neurons of the olfactory bulb ( via blocking voltage-dependent potassium channel reduces body weight in obese mice ( via inhibition of voltage-dependent potassium channel conductance and enhancement of glutamatergic neurotransmission, could lead to changed excitability of higher olfactory cortical as well as hypothalamic regions to change metabolic states