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190 In general, cyanopyrrolidines such as saxagliptin are competitive inhibitors rather than noncompetitive inhibitors of DPP-IV enzymatic activity since they form reversible covalent bonds with serine residue 630 located within the enzyme's active site

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Clinical trials did not mandate specific times of day, and morning versus evening administration showed comparable results

Long-term use beyond the recommended period increases the risk of physical and psychological dependence

Mickelson and Eric C

gentle circular motions for 10 seconds are enough
