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Second, GLP-1 induces pancreatic cells to secret insulin in response to increased glucose contents, while also restricting glucagon release from pancreatic cells8)

Diabetes 68 , 683695 (2019)

GLP-1 cost disparities highlight need for affordable alternatives The obesity rate in the United States is starting to level off, but it continues to be highest among developed nations

However, clinical research increasingly recognized that patients with metabolic diseases frequently experience clusters of systemic complications, including heart failure (HF), chronic kidney disease (CKD), and fatty liver disease, that single-target drugs historically failed to address comprehensively

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