do you plateau on semaglutide 7 Reasons You're Not Losing Weight (& What To About It) Ozempic Plateau? Why Your Gut

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Modica S, Straub LG, Balaz M, Sun W, Varga L, Stefanicka P, Profant M, Simon E, Neubauer H, Ukropcova B, Ukropec J, Wolfrum C

GLP-1 and the reduction of food intake Following the demonstration that intracerebroventricular administration of GLP-1 inhibited food intake in mice and rats, treatment of animals with peripherally administered GLP-1RA was associated with reduction of food intake and weight loss (1)

Patients will see the most progressive weight loss a few months into treatment

A dedicated phase 2a substudy in people with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) used MRI to measure liver fat and found that, after 24 weeks, retatrutide reduced relative liver-fat content by about 81% at the 8 mg dose and about 82% at 12 mg, versus essentially no change on placebo

This suggests a need for further investigation