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In addition, both have extra-pancreatic functions that impact appetite regulation in the CNS

In particular, the gutbrain axis has garnered attention as a bidirectional system capable of regulating mood, motivation, and reward-seeking behavior via endocrine, neural, and immune pathways [3,4]

Most patients notice appetite suppression within the first few weeks of treatment

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ACSL4 deletion or treatment with liproxstatin-1, an inhibitor of ferroptosis, significantly reduced 4-hydroxynonenal (4-HNE) levels, while the level of 4-HNE in esophageal cancer tissues after radiotherapy was significantly associated with better clinical prognosis of cancer patients (257)