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84 A phase II trial enrolled participants with T2DM and BMI of 2550 kg/m 2 taking Metformin therapy and assigned them to receive survodutide, semaglutide or placebo
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Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]
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