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Glucagon-like peptide receptor agonists (GLP-1 RAs or GLP-1 agonists for short) are drugs manufactured to bind to GLP-1 receptors, essentially mimicking and magnifying the effects of these hormones

The flagship trial STEP-1 (published in NEJM , 2021) found a mean weight reduction of ~14.9% of body weight with semaglutide 2.4 mg vs ~2.4% with placebo over 68 weeks ( [12] )

Whats more, they replicated the same analyses in a separate cohort of patients with type 2 diabetes mellitus by comparing semaglutide with non-GLP1R agonist anti-diabetes medications

In contrast, the risk for right heart failure among those using GLP-1 receptor agonists did not significantly differ from the risk among those not using GLP-1 receptor agonists

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The concept sounds simple