semaglutide method of action Mechanism of GLP-1 [25] A Pharmacological and Clinical Overview

However, rapid weight loss may include both fat and lean muscle loss if nutrition and exercise strategies are not carefully managed

Overall, GLP-1 RAs appear to be more efficacious than DPP4 inhibitors in people with type 2 diabetes in terms of improving glycaemic control and reducing body weight (Gilbert and Pratley, 2020)

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Clinics should avoid guarantees, exaggerated outcomes, or statements that could be interpreted as misleading

After 36 weeks, exenatide significantly decreased energy intake during a free buffet meal compared to placebo [1800 kJ (430 kcal), 95% CI 3184 to 418 kJ, P = .02 compared to placebo] change from baseline to 36 weeks

DOI: 10.1111/dom.70698 Malik IO, Petersen MC, Klein S