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Beyond the Scale: Cardiometabolic Promise In the Lancet trial, low-density lipoprotein cholesterol fell by 1619 %, and C-reactive protein by 28 %, hinting at cardiovascular-risk attenuation
By activating both GIP and GLP-1 receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning insulin is released primarily when blood glucose levels are elevated

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Finally, the triple agonist retatrutide (GIPR, GLP-1 receptor, and glucagon receptor) is currently under clinical investigation with promising early results (17)
The combination therapy addresses weight management while also targeting metabolic health concerns

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