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GLP-1 inhibits adenosine triphosphate (ATP)-regulated potassium (K + )channels, increases activity of L-type voltage gated calcium channels, and triggers opening of non-specific cation channels through PKA and exchange protein directly activated by cAMP (EPAC), two cAMP-dependent processes [48], [49]

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Combining GLP-1 receptor agonists is generally contraindicated
Studies in animal models suggested that activating the GLP-1 receptors (GLP-1Rs) in the brain improves neuroinflammation, neurogenesis, and synaptic plasticity
