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Exenatide repairs renal tubular epithelial cells damaged by a HFD by reversing SIRT1 downregulation, inhibiting reactive oxygen species, and blocking mitochondrial apoptosis [224], [225]

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Therefore, patients who need these medications to treat their chronic conditions, whether T2DM or obesity, are unable to obtain these medications and are taking a hit to their treatment goals

People with pre-existing depression or anxiety may be more vulnerable

The evidence reveals both shared and condition-specific mechanisms through which GLP-1 physiology impacts eating behavior and body weight regulation

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