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Labeling adds a further challenge

The sustained, steady receptor activation appears to be better tolerated than the repeated peaks and troughs of shorter-acting agents
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GPhC registration and UK-based prescribers should be treated as essential, not optional

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Tirzepatide data from the SURPASS trials showed gallbladder events (cholelithiasis, biliary colic, and cholecystectomy) in approximately 0.6% of treated patients versus none in placebo groups
