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However, the GI side effects (particularly vomiting and diarrhea) can cause dehydration, which hits people with existing kidney disease much harder

[2] Reduction In Hospitalization For Heart Failure: Jardiance Is The Better Option One class of drugs, known as SGLT2 inhibitors, has a clear benefit over the other class, known as GLP-1 drugs, in reducing hospitalization for heart failure, the study found

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The Medicare GLP-1 bridge program is a separate pilot run by CMS with Humana, outside your standard Part D plan, and it has its own eligibility rules and $50 monthly co-payment

That is a different story from spacing doses under supervision. What structured de-escalation is and what it is not The authors described reduced-frequency maintenance as structured de-escalation that could reduce treatment burden without sacrificing key outcomes, at least in selected patients