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3 This has led to GLP-1 receptor agonists being licensed to promote weight loss in the setting of obesity

The primary mechanism of action involves stimulating insulin secretion from pancreatic beta cells in a glucose-dependent mannermeaning it only triggers insulin release when blood sugar levels are elevated

Manning Fox, Michael J

Working together to develop this novel obesity therapy represents an important addition to Lillys efforts to advance innovative treatment options for patients with metabolic disorders. Those efforts include Lillys own internally developed oral obesity candidate orforglipron, a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist

In a cohort of patients who had undergone at least one prior line of anti-PD-(L)1 therapy, Balversa cut the risk of death by 36% versus chemotherapy

But in practice, these are fundamentally different compounds with different receptor profiles, different side effect landscapes, and different outcomes for the people who use them