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In most major obesity trials, GLP-1 therapy was: Escalated to high or maximum tolerated doses Stopped abruptly, not down-titrated Followed by little or no continuation of structured lifestyle support In the STEP-1 extension trial (semaglutide 2.4 mg), participants who discontinued therapy regained approximately two-thirds of their prior weight loss over the following year
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A clinical framework is proposed to integrate pharmacotherapy with lifestyle and psychological interventions
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New research finds semaglutide decelerates biological aging in people with HIV, sparking hope for broader longevity breakthroughs.
