what meds are glp 1 New GLP-1 Guidelines for Type 2 Diabetes in 2025 What to Make of the

Observational Studies on GLP-1R Agonists and Substance Use Outcomes The clinical potential of GLP-1RAs in modulating substance use behaviors has been increasingly recognized through preclinical and early translational studies

Additionally, in the SELECT trial, adults with obesity and without diabetes receiving semaglutide had a 20% lower risk for major adverse CV events compared with placebo (HR = 0.8

J Am Heart Assoc 2022;11(19):e025545

However, the incidence of gastrointestinal events, discontinuations due to adverse events, and mean increase in pulse rate were higher with orforglipron than oral semaglutide

Remarkably, the survival benefits of GLP-1RAs, as observed in CVOTs, typically manifest over a more extended period than what our Kaplan Meier curves suggest 15,33

Studies have shown that GLP-1 and its analogs have anti-inflammatory properties