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The comparative benefits of combination therapy have been demonstrated both for primary and secondary prevention

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In vitro studies: Animal Models: Conducting controlled studies in animal models (e.g., obese or diabetic mice) to assess the combined effects on weight loss, glucose metabolism, insulin sensitivity, and overall metabolic health

hypoglycemia was observed in 5 of the 7 healthy subjects but none the patients with diabetes therefore it was concluded that hypoglycemia shouldnt be expected in patients with type 2 diabetes treated with GLP-1 based therapies