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Such lipotoxicity induces cardiotoxic effects through bioactive sphingolipids like ceramides and diacylglycerols (DAGs) (82)

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21 Although the long-term retinal effects of GLP-1RA in DR arent fully understood at this time, an ongoing trial is investigating the extended effect of semaglutide on DR after 5 years of treatment

281,309 Moreover, reducing inflammation may slow down the degradation of joint cartilage, providing long-term joint protection

The core problem is a cascade: insulin resistance drives excess androgen production, which disrupts normal follicle development