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Early optimism in the use of GLP-1 therapies for Parkinsons disease has been tempered by the recent failure of a Phase III exenatide trial which did not show any benefits of slowing Parkinsons progression 10

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For semaglutide, the primary compound patent (US 8,129,343) expires in December 2031

The potential side effects of GLP-1 drugs are no fun: nausea, vomiting, fatigue, diarrhea, constipation

doi: 10.1037/amp0000059