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Interestingly, the GLP-1/estrogen conjugate has shown a higher efficiency for decreasing body weight and improving glycemic control in obese mice than when administrated individually [133]

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Its fine to say that your supplement increases X or Y in the body, but what effect does that increase have
However, given the larger number of users taking the medications, it could have widespread impact

Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety

Janssen, et al (2012)
