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Musculoskeletal Applications Musculoskeletal applications of GLP-1 RAs gained substantial momentum in 20242025, particularly for the management of osteoarthritis and sarcopenia, with systematic reviews identifying consistent signals supporting favorable structural, protective, immunomodulatory, and analgesic effects [166]

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Dietary modifications to reduce gastrointestinal symptoms: Eat smaller, more frequent meals rather than large portions Choose bland, easily digestible foods during the initial treatment period Avoid high-fat, spicy, or heavily processed foods that may exacerbate nausea Eat slowly and chew thoroughly to accommodate delayed gastric emptying Avoid lying down immediately after eating Medication administration tips: Administer injections at a consistent time weekly, preferably when you can rest if nausea occurs Follow the prescribed dose escalation schedulegradual titration improves tolerability Never increase the dose faster than recommended to minimise side effects When to consider symptomatic treatment: Your prescriber may recommend anti-emetic medication for persistent nausea or loperamide for diarrhoea

03 Modify behavior This unique treatment leaves patients feeling fuller longer and allows them to more comfortably make modifications to diet and portion size

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