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Overall, as GLP-1RAs become increasingly prescribed, further pharmacovigilance studies are warranted, noted the authors

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90 A recent clinical trial assessing the histological benefits of tirzepatide for MASH reported that tirzepatide 5 mg achieved at least one-stage improvement in fibrosis for 55% of patients without worsening MASH, and 43.6% of patients experienced MASH resolution with no worsening fibrosis

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist mimicking the natural GLP-1 hormone in appetite regulation

Cell proliferation was evaluated by measuring the fluorescence intensity of propidium iodide (PI) as previously described (23)

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