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when tirzepatide is paired with the anti-myostatin agent apitegromab, sarcopenic risk is mitigated by nearly halving lean mass loss compared with dual-incretin monotherapy (14.6% vs

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This is evidenced by up-regulation of glycolytic enzyme expression, increased rates of glucose uptake and consumption, as well as augmented ATP content, insulin secretion and glycolytic flux after removal of Exendin-4

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