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Some of the more severe side effects include: Pancreatitis : Inflammation of the pancreas (pancreatitis) can occur, causing severe abdominal pain that radiates to the back, along with nausea and vomiting

SUSTAIN-6 reported a reduction in non-fatal stroke, while the Harmony Outcomes trials observed a reduction in non-fatal MI, and the LEADER trial observed fewer deaths from cardiovascular causes in the liraglutide group than in the placebo group

Higher doses may need to be refilled more often

Effects on Hepatic Metabolism Whereas GLP-1 and GIP receptors are not expressed in hepatocytes, the glucagon receptor is abundantly expressed in hepatic tissue, facilitating hypolipidaemic activities in the liver [71]

The same brain command center that controls hunger and satiety signals is also involved in addictions, Burak said

This suggests that ChREBP and downstream associated transcription factors might also play a role in the observed metabolic shift
