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(19) Bone formation indicators alkaline phosphatase (ALP) and osteocalcin (OC) increased with the addition of liraglutide, meanwhile bone resorption indicators tartrate-resistant acid phosphatase (TRACP) and cross-linked carboxy-terminal telopeptide of type I collagen (CTX-I) were reduced

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Summary: IBS is not a formal contraindication to Wegovy, but the medication's gastrointestinal side effects may worsen existing bowel symptoms and require careful monitoring

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Rodent studies revealed that administration of GLP-1R agonists to the central or peripheral nervous system can activate a subset of GLP1Rexpressing neurons and produce weight loss [10, 11]