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Thinking about Body Health Beyond Weight Loss The future of obesity treatment may ultimately stretch far beyond weight loss

Retinal thinning was observed even among those without clinically apparent DRD, indicating that neuroretinal changes may precede overt vascular retinopathy

Pros: Can be taken without food and water restrictions and therefore suitable for those with busy or unpredictable schedules Convenient once-daily pill lowers A1C by an average of 1.3% to 1.6% from a baseline of 8.0%, compared to placebo at 40 weeks in the ACHIEVE-1 trial Significant weight loss results in the ACHIEVE-1 trial, where participants taking orforglipron lost an average of 16.0 lbs (7.9%) at the highest dose

Hernan MA, Robins JM

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By protecting neurons from mast-cell-induced toxicity, these peptides may help to preserve gut motility and vagal tone, reduce neuroinflammation and abdominal pain, improve digestion and absorption through ENS integrity, and stabilise mood and cognitive function via gutbrain communication