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This differentiation can be achieved through variations in dosage form, strength, or combinations, provided there is a documented medical need for such modifications. This pathway allows compounding pharmacies to serve patients with specific requirements not met by the standard FDA-approved medications

Patients should be advised to contact their IBD team or GP for new or changing symptoms, and to use NHS 111 or attend A&E for severe acute symptoms

We focus on your individual needs during the switch, making sure youre never in the dark

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This causal link is supported by robust molecular evidence from models such as the db/db mouse, in which nuclear localization of ATF4 in -cells correlates with diminished insulinotropic responses and accelerated mass loss (Lee et al., 2023) ( Figure 1 , left)

To address these limitations and improve evidence-based guidelines for clinical practice, large-scale prospective studies and standardised real-world analyses are required in the future