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But that range hides enormous variation in what you actually get for your money

The exact mechanism remains unclear, but several possibilities have emerged: Autonomic Modulation: GLP-1 agonists may reduce parasympathetic (vagal) tone or enhance sympathetic drive, leading to a faster resting heart rate

This prevents backflow and ensures the full dose is deposited in the subcutaneous tissue

Mild itching may resolve as your body adjusts, but persistent or severe itching, especially with rash, swelling, or breathing difficulties, requires prompt medical assessment via your GP, NHS 111, or emergency services

Constipation typically appears within the first one to two weeks of starting semaglutide and often resolves within four to six weeks as your body adapts

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