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Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet

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Since a glucagon antagonist can inhibit hepatic glucose output, creating a bifunctional molecule that is an agonist to the GLP-1 receptor (GLP-1R) and an antagonist to the glucagon receptor (GR) simultaneously may be pharmacologically significant for modulating the overall glucose in the body in multiple ways

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