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However, there are a number of putative mechanisms

The lean-mass loss that follows is a consequence of losing weight quickly, the same physiology seen with dieting or surgery, rather than a drug effect on muscle itself

Currently, taking glucose sensitizing agents, including metformin, SGLT-2 inhibitor, and GLP-1 agonist, is an effective way of lowering insulin levels and controlling PDA development at the same time

However, that change might not be reflected in the patient's chart, making it an important occurrence worth further understanding

A non-significant reduction in coronary plaque volume, decrease in liquid plaque volume, and a decrease in non-HDL cholesterol was observed in the sitagliptin group [81]

Moreover, this secretion is stimulated by GLP-1 only, then glucose levels increase [70]