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These data come from Cosmos, a HIPAA-defined Limited Data Set of more than 214 million patients from 218 Epic organizations including 1,235 hospitals and more than 26,800 clinics, serving patients in all 50 states and Lebanon

Additionally, changes in dietary intake that often accompany these medicationssuch as reduced fat consumption or altered meal timingcan independently affect bowel patterns

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The EHR cohort was younger and had a larger proportion of men than the survey cohort (median age 44 years versus 52 years, and 37% male versus 18%), and both of these factors may contribute to some of the apparent difference in weight loss efficacy between self-report and EHR data

In this Perspective, we summarize data on cancer incidence from trials and registries in individuals with type 2 diabetes, describe the actions of GLP-1 medicines on preclinical cancer models and highlight possible direct and indirect mechanisms linking GLP-1R signaling to cancer development and progression