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We confirmed the robustness of our findings for the composite outcomes, as complementary analyses using both a Fine-Gray model and a cause specific hazard model with time varying inverse probability-of-death censoring weights yielded consistent results on both relative and absolute scales (supplementary figures S5 and S7)

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The dose is adjusted based on basal blood glucose level every three days (Table 1)

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However, there is wide variability between patients, with some losing much more weight, and others receiving little to no benefit