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Because the two peptides hit two separate receptors that both feed the same GH pulse, they are described in research as synergistic rather than additive: GHRH-driven and secretagogue-driven signals combine at the pituitary

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doi: 10.2337/diacare.25.8.1398 [DOI] [PubMed] [Google Scholar] 65.Plum A, Jensen LB, Kristensen JB

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The brain regions involved include the hypothalamus, hippocampus, and brainstem, which express GLP-1 receptors