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Wegovy is a glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for weight management in adults with obesity (BMI 30) or overweight (BMI 27) with weight-related comorbidities

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Aspiration pneumonia: In cases described in litigation, some patients allegedly aspirated stomach contents due to impaired gastric motility, causing lung complications

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The SURMOUNT-5 trial demonstrated that Zepbounds dual-agonist approach produces approximately 6% more weight loss compared to Wegovys GLP-1-only mechanism

The primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin is only released when blood glucose levels are elevated Suppressing glucagon release from pancreatic alpha cells, which reduces hepatic glucose production Slowing gastric emptying , which helps moderate post-meal blood glucose spikes Reducing appetite through central nervous system effects, leading to decreased caloric intake and weight loss Examples of GLP-1 receptor agonists available in the UK include exenatide (Byetta, Bydureon), liraglutide (Victoza for diabetes, Saxenda for weight management), dulaglutide (Trulicity), lixisenatide (Lyxumia), and semaglutide (Ozempic/Rybelsus for diabetes, Wegovy for weight management)