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According to Centers for Medicare & Medicaid Services (CMS) standards, even intensive behavioral treatment for obesity requires reassessment at the six-month mark, with continued therapy contingent upon achieving at least 3kg weight reduction

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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Tang C, et al

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In metabolic conditions such as diabetes, prolonged hyperglycemia can damage small nerve fibers through multiple pathways including oxidative stress, accumulation of advanced glycation end products, and microvascular insufficiency affecting nerve blood supply