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The mice were sacrificed by cervical dislocation at 5, 15, 30, 60, 150, and 360 min after administration (n = 4 for each time point), followed by immediate resection of each organ including the pancreas, kidney, liver, spleen, lung, and blood

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Regarding the central mechanism of feeding regulation, proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are key anorexigenic neurons

These effects result from slowed gastric emptying and are generally most pronounced during dose escalation

At one year, compared with placebo, weight loss was 4.1 kg in the exercise group, 6.8 kg in the liraglutide group, and 9.5 kg in the combination group, highlighting the additive benefits of combining pharmacotherapy with exercise [6]

39 Given that rates of obesity are gradually increasing over time, 40 morbidity and mortality due to progressive NAFLD will likely manifest at a younger age, leading to significant clinical and economic burden over the next decades