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Trial data have shown decreases in serious cardiovascular complications, including cardiovascular mortality, nonlethal heart attacks, and nonfatal cerebrovascular accidents, among individuals with type 2 diabetes and pre-existing cardiovascular pathology or high cardiovascular risk [3,5,13,14,37]

Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids

In practice, GI side effects especially constipation are among the most common reasons patients struggle to stay on these medications

Caitlin Beale, MS, RDN Tester Caitlin Beale, MS, RDN, is a registered dietitian and freelance health writer with experience in clinical nutrition, education, research, and private practice

Introduction People with type 2 diabetes are prone to developing hyperkalemia, especially those with comorbid conditions such as heart failure and chronic kidney disease.123 However, several drugs that improve clinical outcomes in people with type 2 diabetes and related comorbidities increase serum potassium levels, such as inhibitors of the renin-angiotensin-aldosterone system.456789 Hyperkalemia is associated with a risk of life threatening cardiac arrhythmias and increased mortality,10 and the occurrence of hyperkalemia frequently leads to dose reduction or discontinuation of cardiorenal protective drugs

Gastrointestinal adverse events during follow-up were statistically significant (82)