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The addressable patient expansion is estimated to grow the anti-obesity medication market by 180 million new prescription patients between 2027 and 2032

Although these discrepancies may be because of the different techniques used to measure the receptor protein, namely autoradiography vs immunohistochemistry, they may also be related to the antibodies used and their level of characterization and validation, as mentioned by Drucker 11 and Pyke et al

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Higher doses can lead to an increase in zinc levels in breast milk, as seen in six mothers with Wilsons disease who took 50150 mg of zinc daily

The shorter trial duration of SUSTAIN 6 and PIONEER 6 compared with the 3.5-year trial duration of LEADER might also explain the observed discrepancy in treatment effect across baseline eGFR subgroups [2], because eGFR decline is a continuous process and a follow-up of 2 years is recommended to reliably predict a treatment effect based on changes in eGFR slope [26]

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