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The results of a trial of semaglutide in obese patients with HFpEF showed a significant amelioration of symptoms and improvements in motor function and weight loss compared with patients treated with a placebo

Nauck et al., 2014

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The safety and tolerability of LY were monitored through vital signs, laboratory data, and adverse events (AEs)

Getting Started: Your First Steps Before diving into the details, heres what you should do right now if youre planning pregnancy: Stop GLP-1 after coordinating with your prescribing doctor (plan for 2-3 months before trying to conceive) Start prenatal vitamins today (400-800mcg folic acid) Switch to more reliable birth control if youre on pills (consider IUD or barrier methods) Schedule a preconception visit with your OB/GYN Start tracking cycles (app or paper) Write down your GLP-1 details (drug, dose, last injection date) Understanding the Pregnancy Safety Concerns Before diving into timelines and action plans, lets establish why this matters and what we actually knowversus what were still learning

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