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In a pooled analysis of clinical trials assessing patients with heart failure with preserved ejection fraction (HFpEF), including the STEP HFpEF and STEP HFpEF DM trials, as well as in the FLOW and SELECT trials, semaglutide improved New York Heart Association (NYHA) class IIIV symptoms, physical limitations, exercise function, associated with a 30% reduction of N-terminal pro-brain natriuretic peptide and a 31% reduction in the composite endpoint of cardiovascular death and the need for treatment intensification or hospitalization for heart failure-related events (HR 0.69

Hypoglycemia: Particularly when used with other anti-diabetic medications

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Since semaglutides patent expired in India in March 2026, generic prices have fallen by roughly 80%, with monthly costs now starting around 1,290 to 5,000 compared with 8,800 to 16,400 for older branded options

Lixisenatide is administered OD 16

These symptoms are typically most pronounced during the first few weeks of treatment and often improve with time